New proteins discovered connected to ALS

Research discovers potential new therapeutic target for ALS

J. Gavin Daigle, a PhD candidate at the LSU Health New Orleans School of Graduate Studies, is the first author of a paper whose findings reveal another piece of the Amyotrophic Lateral Sclerosis (ALS) puzzle. Working with mentor Udai Pandey, PhD, a former member of the Genetics Department faculty at LSU Health New Orleans now at the University of Pittsburgh Medical Center, the team identified a protein that can protect against the toxic degeneration of cells in diseases like ALS, also known as Lou Gehrig's disease. The work is published this month online in the journal Acta Neurpathologica.

Revealing the intra-cellular mechanism underlying ALS

A new study uncovering the mechanism behind amyotrophic lateral sclerosis (ALS or also Lou Gehrig's disease) has brought doctors a step closer to identifying drug targets for the malady. Tsukasa Uchida and collaborators at Kyoto University have identified proteins associated with cancer suppression and prevention of hypoxia as key players in the progression of ALS.